Rheumatoid Arthritis (RA) is characterized by inflammation of the joints which can lead to progressive joint destruction and consequently impair the quality of life.
Early aggressive therapeutic intervention is required to prevent irreversible joint damage and therefore it is important to diagnose RA as early as possible.
Anti-cyclic Citrullinated Peptide (anti-CCP) Antibodies and Rheumatoid Arthritis
Anti-CCP antibodies are important markers for diagnosis and prognosis in rheumatoid arthritis (RA), because they:
- Are as sensitive as, and more specific than rheumatoid factor (RF) in early and fully established disease
- May predict the eventual development into RA when found in undifferentiated arthritis
- Are a marker of erosive disease in RA
- May be detected in healthy individuals years before onset of clinical RA
Many extensive studies have confirmed that Anti-CCP2 test has superior diagnostic accuracy over the RF test.