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  • Milk Allergy

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    Cow's milk is one of the most common food allergies in children, perhaps because it is usually the first foreign protein (substance) encountered by infants.

    Cow's milk allergy (CMA) affects about 2-7.5% of infants. Unfortunately, in CMA patients, 50% will develop an allergy to other food proteins (e.g. egg, soya, peanut) and 50-80% will develop an allergy against one or more inhalant allergens (e.g. grass pollens, house dust mite, cat) before puberty. There is also a higher risk of developing other allergic diseases such as asthma or eczema.

    Small amounts of milk protein can pass through the breast milk and may cause allergic signs and symptoms in some infants. In this case the mother must exclude all dairy products from her diet, take a calcium replacement, and continue to breast feed under the supervision of a dietitian.

    Milk Allergy

    Cost Rs. 1200/-

    PAEDIATRIC ALLERGY PANEL

    Cost Rs. 4900/-


    Paediatric Allergy Panel Tests:

    • Testing for Milk
    • Caesin
    • Alpha-lactalbumin
    • Beta-lactoglobulin

    Milk Allergens

    Milk contains many protein fractions (allergens) that cause allergic reactions. The two main components are whey and casein, and an individual may be allergic to either or both. The casein is the curd that forms when milk is left to sour, and the whey is the watery fraction which is left after the curd is removed.

    The whey fraction (20%) contains mainly alpha-lactalbumin and beta-lactaglobulin and is most likely to produce the IgE-antibodies (Immunoglobulin E) and causes the most clinical problems. These IgE-antibodies can be tested for in the blood, and by skin prick testing. The whey proteins are altered by high heat, and so the whey sensitive person maybe able to tolerate evaporated, boiled or sterilised (Long Life) milk and milk powder. ?-Lactoglobulin is the major whey protein of cow and sheep's milk (~3 g/l), and is also present in many other mammalian species; a notable exception being humans.

    Casein (80%) is heat stable and is the most important allergen in cheese. The harder the cheese, the more casein is formed. This is the least allergenic for those individuals allergic to the whey fraction. Extensive heating may reduce only, but not eliminate, the allergenicity of the protein fractions.

    Cross-reactivity

    There is cross-reactivity among milk proteins obtained from cows, goats and sheep. Only the whey fraction in the goat's milk differs from that in the cow's milk. Goat's milk is tolerated by only 40% of children who are allergic to cow's milk.

    What is Milk Allergy/Intolerance?

    Clinically abnormal reactions to cow's milk protein (CMP) may be due to the interaction between one or more milk proteins and one or more immune mechanisms. Reactions where the immune system is involved, which are mainly immediate IgE-mediated reactions (involving IgE-antibodies) are defined as cow's milk protein allergy (CMPA). Reactions not involving the immune system are defined as cow's milk protein intolerance (CMP).

    Clinical Types of Milk Allergic Reactions

    Reactions can be immediate or start several hours or even days after the intake of moderate to large amounts of CM.

    • Type 1 - Symptoms start within minutes of intake of small volumes of CM. Mainly causes skin problems, eczema or urticaria (hives). May have respiratory (runny nose, wheezy chest) or gastro-intestinal (vomiting and diarrhoea) symptoms.
    • Type 2 - Symptoms start several hours after intake of modest volumes of CM; mostly symptoms of vomiting and diarrhoea.
    • Type 3 - Symptoms develop after more than 20 hours, or even days after intake of large volumes of CM. Symptoms include diarrhoea, with or without respiratory or skin reactions.

    TABLE 1. Symptoms that could indicate a possible milk allergy

    • excessive colic
    • recurrent bronchitis
    • recurrent diarrhoea
    • recurrent "colds," sinusitis,
    • vomiting, abdominal pain
    • ear infections
    • excoriated buttocks
    • fluid behind ears
    • rash, hives and eczema
    • wet and wheezy chest
    • chronic runny nose
    • coughing
    • nasal stuffiness
    • irritability
    • failure to thrive

    TABLE 2. Label Ingredients that may contain milk protein

    • milk (also buttermilk)
    • margarine
    • milk solid
    • cream
    • whey
    • cheese
    • whey powder
    • butter
    • curds
    • yoghurt
    • lactose
    • lactalbumin
    • caseinate (potassium, sodium, calcium, magnesium, zinc and iron caseinates.

    How is Milk Allergy Diagnosed?

    Only the immediate milk reactions that develop after a few minutes are most likely to give a positive blood or skin test, as these detect IgE that is involved in the immediate type reaction. Nearly 60% of milk reactions in the young child are the delayed type (intolerant) and therefore unlikely to give positive results with the blood and skin tests. The diagnosis is then made by the Elimination-Challenge Test. This should demonstrate the relief of symptoms on the removal of milk from the diet and the recurrence of symptoms when re-introduced. This Elimination-Challenge Test should be supervised by the doctor and the dietitian.

    Guidelines for Nutritional Management

    No milk-free diet should be undertaken without the supervision of a dietitian, who will provide milk-free recipes and a list of alternative products to ensure a nutritionally adequate diet, in order to avoid a deficiency of calcium, riboflavin and vitamin D.

    All pregnant and breast-feeding mothers, children and adults on a dairy-free diet, must have their calcium replaced, otherwise this could lead to dental and bone problems. The correct dosage and type of calcium supplement is to be advised by the doctor and dietitian.

    Milk may be present where you least expect it. For example in viennas, sausages, fish fingers, pie crusts, biscuits like Provita and breakfast cereals.

    Milk substitutes in the form of soya or hypo-allergenic whey and casein formulas may be given to the young infant on the advice of the doctor. Unfortunately they are extremely expensive. 25% of milk-allergic infants may become allergic to the soya protein. What then is the alternative? Home-made meat-based formula (e.g. lamb, chicken, turkey) may be advised by the dietitian.

    Will my child outgrow the milk allergy?

    Most children will outgrow their CMA, +60% at 4 years and +80% at 6 years. Some patients retain the allergy throughout life. If the milk is strictly excluded from the diet for + 2-3 years, the child then has an 80% chance of tolerating the milk in small amounts again. CMA may be acquired later in life

    Differences between Milk Allergy and Lactose Intolerance

    Milk allergy should not be confused with lactose intolerance. A food allergy is an overreaction of the immune system to a specific food protein. When the food protein is ingested, in can trigger an allergic reaction that may include a range of symptoms from mild symptoms (rashes, hives, itching, swelling, etc.) to severe symptoms (trouble breathing, wheezing, loss of consciousness, etc.). A food allergy can be potentially fatal.

    Unlike food allergies, food intolerances do not involve the immune system. People who are lactose intolerant are missing the enzyme lactase, which breaks down lactose, a sugar found in milk and dairy products. As a result, lactose-intolerant patients are unable to digest these foods, and may experience symptoms such as nausea, cramps, gas, bloating and diarrhea. While lactose intolerance can cause great discomfort, it is not life-threatening.

    For more information, please contact us at +91 22 66949876 / 9833141024 or email us at disha@pathologylabindia.com for any test requirement or any query related to our pathology lab

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